Colorcon provides wide range of excipients which includes methocel lv. This means unmatched fl exibility for fi netuning matrix release profi les and optimizing ingredient costs. Import data and price of methocel k100 premium zauba. All of these products are available in controlledrelease cr. It is well established for use in the pharmaceutical industry. Methocel dc2 premium excipients saving the industry. Methocel premium cellulose ethers, specifi cally the k and e series of products, have been the preferred brand of hypromellose in matrix systems for many years.
Methocel k100m premium cr hypromellose 2208 usp fagron. Only methocel premium products can be used in controlledrelease formulations table 1. Methocel k100m premium hydroxypropyl methylcellulose. I would like to use this as a supplement similar to citrucel but without the added dyes and sweeteners. A wide vary of viscosity sorts are available in market for commercial purpose. Methocel product information premium cellulose ethers methocel 1 an introduction to methocel, premium cellulose ethers methocel cellulose ethers are watersoluble polymers derived from cellulose, the most abundant polymer in nature. The usp grade designation indicates that this item meets or exceeds the requirements of the u. Methocel cellulose ethers technical handbook department of. Typical products used in controlled release include methocel k100 premium lv, k4m premium, k15m premium, k100m premium, e4m premium, and e10m premium cr. These polymers have been developed to optimize dry powder processability while maintaining the same viscosities, degrees. Methocel k100lv premium dc2, methocel k4m premium dc2 and methocel k100m premium dc2.
Solutions containing methocel k4m are thixotropic and as such have good lubricity and are easy to spread. Premium cellulose ethers to include methocel k200m premium and k200m premium cr for use in extended release matrix formulations. Methocel k100m premium cr hypromellose 2208 usp about fagron fagrons strategy is focused on the optimization and innovation of pharmaceutical compounding. Methocel k100 premium about fagron fagrons strategy is focused on the optimization and innovation of pharmaceutical compounding. Methocel k100m hypromellose 2008 usp sds preparation date 07032017 page 3 of 7 safety data sheet section 5 firefighting measures continued unusual fire and explosion hazards. Properties of methocel k100m compared to methocel k200m poly mer attribute k100m premium k100m. Methocel k100m premium hydroxypropyl methylcellulose msds. Using methocel cellulose ethers for controlled release of. Hot gels formed using methocel may be subject to a small amount of leeching of free water when the gels are heated, this can be controlled with the use of a water binding ingredient such as xanthan gum or locust bean gum. For example, methocel premium cellulose ethers from dow chemical.
There are two premium types, methylcellulose mc and hypromellose hpmc, meeting usp, jp and ph. Hopefully we can all learn more about methylcellulose by discussing it. It has a very high viscosity of 100,000 cp this product is certified kosher pareve by the orthodox union. Generally aqueous solutions are prepared, though hpmc. Using dow excipients for controlled release of drugs in. Methocel these are typical properties, not to be construed as specifications premium products. Methocel is used as rheology modifiers, binders, film formers for a variety of industrial applications including adhesives and sealants, coatings, ceramics, gelled fuels, inks, paint stripper, polymerization aid and paper. It has a medium viscosity of 4000 cp this product is certified kosher pareve by the orthodox union get the recipe 4. How to prepare solutions of methocel in nonaqueous. The methocel product range encompasses methylcellulose and hydroxypropyl methylcellulose hypromellose each available in different grades, physical forms and a wide range of viscosities. Chemistry of methocel cellulose ethers a technical. Why methocel premium products are often the brand of choice.
Three direct compression grades are currently available. Hydroxypropyl methylcellulose hpmc thickener with low substitution. Methocel cellulose ethers are watersoluble methylcellulose and hydroxypropyl methylcellulose polymers. No regulatory data sheets are available online for this product. It is used as a thickener for coatings and adhesives and as a binder to improve green strength in ceramics. Can it be ingested safely just sprinkled on a salad or on fruit or other food. Methocel cellulose ethers are watersoluble polymers derived from cellulose. Comparison of methocel grades for pharmaceutical applications methocel premium products. Methocel k100m premium and eudragit rs po were placed in collette150.
Methocel k100m premium cr hypromellose, substitution type 2208, 3,550 mpa. Theyre derived from pine pulp, the most abundant polymer in nature, and used as thickeners, binders, filmformers and for waterretention. The family of methocel premium products is the broadest in the industry. Methocel k100m premium hydroxypropyl methylcellulose dow. These new offerings provide formulators with additional tools to meet their needs for extended releasematrix formulation s. View detailed import data, price, monthly trends, major importing countries, major ports of methocel k100 premium. Methocel k4m is an hpmc thickener with moderate hydroxypropyl substitution. Methocel dc2 premium excipients saving the industry time.
Methocel watersoluble cellulose ethers, dupont chempoint. Methocel k15m premium 2208 15 000 methocel k100m premium 2208 100 000 methocel e4m premium 2910 4000 methocel f50 premium 2906 50 methocel e5 premium lv 2906 5 viscosity dynamic. Methocel a, methylcellulose a, methyl cellulose ether physical description. One method of recovery is to rework or reprocess the drug product. E4m, e10m, k15m and k100m, and 3 particle size, such as methocel premium. K3 lv k100 lv k4m k15m k100m e3 lv e5 lv e6 lv e15 lv e50 lv e4m e10m vlv a15 lv a4c a15c a4m viscosity mpa. More about what it is, where to buy it, what its suited for, when to use it, how to use it, recipes using it, and last but not least, experiences using the stuff.
An excellent rheology modifier, binder, film former, and waterretention agent. All encore scientific compendial products are manufactured, packaged, and stored under current good manufacturing practices. Three direct compression grades of methocel dc2 are now available. They enable formulators to create reliable formulas for tablet coatings. Controlled release alliance introducing methocel k200m.
Biochemphysiol actions methyl cellulose is known to have a molecular size that might pass through placenta. They also function as suspension aids, protective colloids and emulsifiers. Investigation of hypromellose particle size effects on drug release. These polymers have been developed to optimize dry powder processability while maintaining the. M0262 page 1 of 5 060397 ckv methyl cellulose sigma prod. Methocel products are used as thickeners, binders and film formers. Methocel k100m hypromellose 2008 usp encore scientific. All spectrum chemical usp products are manufactured, packaged and stored under current good manufacturing practices cgmp per 21cfr part 211 in fda registered and inspected facilities.
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